Obstetric cholestasis: modern recommendations for diagnosis, treatment, management of pregnancy and childbirth

The article is devoted to the most common liver disease which associated with pregnancy – obstetric cholestasis. frequency of this pathology among all disorders in pregnant women almost 27%, second only viral hepatitis. On average, it diagnosed 2–4 cases per 1000 pregnancies. A characteristic feature cholestasis tendency recurrent course future pregnancies, observed 60–70% next This disorder usually manifests itself II or III trimester pregnancy. links pathogenesis and differential diagnosis are briefly described article, main attention paid laboratory diagnostic markers disease, concentration bile acids blood a woman important. An increase ≥10 μmol/L currently criterion for can stimulate release prostaglandins, sensitivity myometrium oxytocin its contractility, 12–44% causes premature birth. Modern recommendations on management childbirth tactics methods treatment also presented article. Today, cholestatic hepatosis women, medicines used that specifically reduce phenomena intrahepatic ursodeoxycholic acid 5-adenosylmethionine, as well symptomatic cholestyramine (or other sequestrants acids), H1-histamine receptors blockers, phenobarbital. convincing evidence effectiveness safety data acid. describes clinical case combined oral contraceptives 10 years prevent an unwanted pregnancy, obviously caused development during patient had timely appropriate treatment. At 37th week vaginal delivery took place. live female child was born, body weight 3000 g, length 48 cm satisfactory condition.